alexa Abstract | Screening of hepatoprotective activity of Madhuca longifolia bark on D-Galactosamine induced hepatotoxicity in rats.

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

In this present investigation the ethanolic extract of Madhuca longifolia bark (EEMLB) was screened for hepatoprotective activity against D-galactosamine (d-GalN) induced hepatiotoxicity in rats. Wistar rats were divided into five groups (n=6). Hepatotoxicity in rats was achieved by intraperitoneal injection of 400mg/kg of d-GalN for five days. Silymarin (100mg/kg) was given as reference standard. The degree of protection against liver toxicity was determined by measuring the serum biochemical parameters viz. SGPT (serum alkaline phosphatase), SGOT (serum glutamine oxaloacetate transaminase), ALP (alkaline phosphatase), total cholesterol and bilirubin (Total and Direct). The result shows that d-GalN has enhanced the levels of SGPT, SGOT, ALP, total cholesterol and bilirubin. Pretreatment with EEMLB (200mg/kg B. wt. and 400 mg/kg B. wt.) brought back the altered levels of biochemical markers to the near normal levels. Histopathological studies also confirmed the hepatoprotective activity of these extracts when compared with d-GalN treated groups. It can be concluded from the result that the extract of Madhuca longifolia bark possesses hepatoprotective activity against D-GalN induced hepatotoxicity in rats.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Samaresh Pal Roy T Kannadasan Ramji Gupta

Keywords

Madhuca longifolia bark, Hepatoprotective, D-galactosamine

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords