alexa Abstract | Separation of complexed semi-synthetic flavonoids by using fused core column in short time

Journal of Chemical and Pharmaceutical Research
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Original Articles Open Access

Abstract

Hydroxyethylrutosides (Troxerutin) is a standardized mixture of semi-synthetic flavonoids obtained by substituting hydroxyethyl groups in the naturally occurring flavonol rutin. Because there are four dissociation hydroxyls in rutin, some fifteen kinds of hydroxyethylrutins can be theoretically synthesized. The good quality of the raw material of a drug and the finished product must include the related impurities in an analytical investigation, and this seemed particularly important to the quality control of Troxerutin. According to the literature, it is clear that, the chromatographic analysis of Troxerutin still problematic as its sample can be considered as a complex sample as it contains plenty of different components. In this study, new HPLC technology named fused- core column was used to separate the major components of Troxerutin bulk powder. Fused – Core silica stationary phases represent key technological advancement in the area of fast HPLC separations. These phases are made by fusing 0.5 μm porous silica. The reduced intra – particle flow path of the fused particles provides superior mass transfer kinetics and better performance at high mobile phase velocities, while the fused – core particles provide lower pressure than sub – 2 μm particles.

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Author(s): Amal Ammar Mohamed Elattug Amal Belaid Sakina Sadaawi Ruwida KamourAkram Ashames Tariq Almog and Shukri Alsharif

Keywords

Troxerutin, UPLC- like method, Fused core column., semi-synthetic flavonoid

 
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