alexa Abstract | sICAM-1 levels in type 2 diabetic atherosclerotic patients

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Atherosclerosis is the main cause of cardiovascular disease (CVD) which is the major cause of morbidity and mortality for diabetic patients. Endothelial dysfunction, which occurs early in atherogenesis, is associated with endothelial expression of the cell-surface adhesion molecules such as ICAM-1 (intercellular adhesion molecule-1). A soluble form of ICAM-1 can be measured in serum. Our study is a prospective cross-sectional study which included 65 participants aged 45-72 years and divided into three groups: type 2 diabetic atherosclerotic patients (n=24), type 2 diabetic non-atherosclerotic patients (n=20) and control group (n=21). Levels of sICAM-1, fasting blood glucose (FBG), total cholesterol (TC), triglycerides(TG), LDL-C and HDL-C were measured. sICAM-1 levels were significantly higher in diabetic atherosclerotic patients compared to diabetic patients (P<0.001) and control group (P<0.001) [470.94±15.24 ng/ml, 336.18±28.32 ng/ml, 273.46±7.2 respectively]. sICAM-1 levels were also significantly higher in diabetic patients compared to control group. Levels of sICAM-1 correlated positively and significantly with FBG and BMI values in diabetic atherosclerotic patients and diabetic patients whereas the correlation was not significant between sICAM-1 levels and lipid parameters levels. Our results showed that type 2 diabetes and atherosclerosis induce significant increase in sICAM-1 levels as a marker of endothelial activation. The coexistence of diabetes and atherosclerosis induces higher levels of sICAM-1.

To read the full article Peer-reviewed Article PDF image

Author(s): Marya Nadim Aldarrouj Faizeh Alqubailey and Mohammad Ali Nahas

Keywords

diabetes, atherosclerosis, adhesion molecules, sICAM-1, type 2 diabetic

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords