alexa Abstract | Significance of Alanine Transaminase in Determining Drug Efficacy in Typhoid Hepatitis

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Objectives: Abnormal liver enzyme levels might be observed with typhoid fever indicating liver involvement. Although, jaundice is unusual and infrequently reported in children, it declares the occurrence of complication. The aim was to evaluate the efficacy of some anti-typhoid drugs in typhoid hepatitis in children through measuring liver transaminase enzymes levels. Patients and Methods: 123 typhoid pediatric patients with high liver transaminase enzymes levels were participated and randomly allocated into 3 groups receiving cefixime (20 mg/kg/day), chloramphenicol (50 mg/kg/day) and amoxicillin (100mg/kg/ day) for two weeks. The obtained data were analyzed using SPSS (version 12) and were expressed as mean ± SEM and the difference among means has been analyzed by student's t test. Results: 64.8% had higher levels of Alanine transaminase than Aspartate transaminase while only 12.5% showed the opposite. At the end of the treatment; 68.3% had normally-returned alanine transaminase level before aspartate transaminase level, while 31.7% had the opposite. Conclusion: Estimation of alanine transaminase level in typhoid hepatitis during and after treatment gives a clue for the efficacy of the used drugs.

To read the full article Peer-reviewed Article PDF image

Author(s): AlRazzuqi Rafi Abdul Majeed AlJawad Faruk Hassan AlJeboori Ali Awad AlNidawi Mahjoob Fahal

Keywords

Aspartate transaminase, Cefixime, Chloramphenicol, Fever abatement.

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us