alexa Abstract | Simple and convenient method of synthesis of N-ethyl-2,6-diethyl aniline and derivatives

Journal of Chemical and Pharmaceutical Research
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Abstract

N-alkylation of 2,6-diethyl aniline and its derivatives using various aldehydes by Pd/C catalyst in aqueous 2- propanol solvent using ammonium formate as insitu hydrogen donor facilitate the formation of N-ethyl-2,6-diethyl aniline and its derivatives which is the simple method of formation of this compound. The reaction proceeds smoothly and selectively with excellent yield at room temperature .Our method presents a facile, economical and environmentally benign alternative for reductive amination.

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Author(s): Sanket Gudekar Rama Lokhande Rajiv Sutar Sanjay Pednekar Sandip Surve and Surekha Kolhal

Keywords

N-alkylation, reductive alkylation, 2,6-diethyl aniline, Pd/C catalyst, Ammonium formate., N-ethyl-2,6-diethyl aniline

 
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