alexa Abstract | Simultaneous administration of mifepristone and misoprostol for medical abortion up to 7 weeks gestation-a pilot study

Journal of Chemical and Pharmaceutical Research
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Most widely used regimen for first trimester medical abortion is 200mg of oral mifepristone followed by 800 mcg misoprostol intravaginally 48 hrs apart. However this interval regimen is associated with lot of apprehension in the waiting period which adversely affects the choice regarding the method termination of pregnancy. The aim of this study was to find out a regimen that is convenient and improves the patient compliance without compromising efficacy. This prospective pilot study was carried out after obtaining ethical clearance. 50 eligible women with gestational age <7 weeks who visited family planning unit for medical termination of pregnancy were included in the study. After taking written informed consent, women received 800 mcg misoprostol intravaginally within 15 minutes of oral administration of 200mg mifepristone. Women were then asked to come for follow up visits on 2nd day, 7th day and 14th day of drug administration. Primary outcome measure was the rate of complete abortion at 2 weeks without the need for suction evacuation. The complete abortion rate with simultaneous regimen was 92% at 2 weeks. The mean induction to abortion interval was 6.8 hours. Mean duration of bleeding was 7.5 days. The overall acceptability rate was 90%.Our study concludes that simultaneous administration is a promising regimen with equal efficacy and higher acceptability as compared to the standard interval regimen for early first trimester medical abortion.

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Author(s): Ritu Sharma Neelu Grover Sudha Salhan and Mamta Gupta


medical abortion, mifepristone, misoprostol, mifepristone- misoprostol interval, mifepristone, misoprostol

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