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Research Paper Open Access
The absorbance maxima of phenylpropanolamine and chlorpheniramine maleate in 0.1 N hydrochloric acid are 257, 265 nm, respectively, whereas, bromhexine hydrochloride shows absorbance maxima at 245 and 311 nm. This paper presents two methods based on first derivative spectrophotometry for simultaneous estimations of these three drugs in combination in pharmaceutical formulations. The first derivative amplitude at 264, 280.6 and 327 nm is utilized for simultaneous estimation. Linearity was validated by Least Squares Method. The results of analysis have been validated statistically. The proposed methods are simple, economical, accurate, reproducible and rapid.
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Author(s): S K Panda A K Sharma L K Sahu