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A new, simple, sensitive, precise and accurate High-performance thin-layer chromatographic method for simultaneous determination of Ritonavir and Atazanavir in their combined tablet dosage form has been developed, validated and used for determination of the compounds in commercial pharmaceutical products. Chromatographic separation was achieved on aluminium plates precoated with silica gel 60 F254 as the stationary phase and chloroform: ethyl acetate: acetone (5:2:3, v/v/v) as a mobile phase. Densitometric measurements of their spots were achieved at 244 nm over the concentration ranges of 800-2800 ng spot-1 and 2400-8400 ng spot-1, with mean recoveries of 98.57 ± 0.35 and 99.16 ± 0.20 for ritonavir and atazanavir respectively. Limit of detection for ritonavir and atazanavir were found to be 300 ng spot-1 and 200 ng spot-1 respectively.
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Author(s): Manoj Gadhvi Anil Bhandari Bhanubhai Suhagia Ishwarsinh Rathod Urvish Desai Arpit Patwari Ketan Variya
High-performance thin-layer chromatography, Ritonavir, Atazanavir