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Two simple, sensitive, rapid and accurate analytical methods have been developed for the simultaneous of ALISKIREN and AMLODIPINE in marketed formulation of pharmaceutical dosage forms. The Q-analysis based on measurement of absorptivity at 279nm and 289nm (as an isoabsorptive point). The second method developed and validated of simultaneous equation using 279/361nm. ALISKIREN and AMLODIPINE at their respective λmax 279nm and 361nm and at iso absorptive point 289nm show linearity in a concentration range of 20-100μg/ml and 5- 25μg/ml.Recovery studies range from 99.51% for Aliskiren and 99.51% for Amlodipine in case of simultaneous equation method Aliskiren was 100.10% and Amlodipine was 100.47%.
Aliskiren, Amlodipine, Q-analysis, Simultaneous equation