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Original Articles Open Access
Montelukast sodium is a leukotriene receptor antagonist, used in the treatment of asthma and Desloratadine is a drug used to treat allergies The combination formulation is used for the treatment of allergic rhinitis. The Ratio spectra derivative spectrophotometric method was developed for the simultaneous determination of Montelukast sodium (MTKT) and Desloratadine (DESLO) in combined dosage forms. The method depends on the use of the first derivative of the ratio-spectra obtained by dividing the absorption spectrum of binary mixtures by a standard spectrum of one of the compounds. The first derivative amplitudes at 218.6 and 262 nm were selected for the determination of MTKT and DESLO respectively. The wavelength interval (Dl) was selected as 8 nm. Methanol was used as the solvent. Both the drugs showed linearity in the range of 5-40μg/ml. The method was validated statistically and recovery studies were carried out. It was found to be accurate, precise and reproducible. The method was applied to the assay of the drugs in marketed formulation, which were found in the range of 99.47% to 101.25% of the labeled value for both Montelukast sodium and Desloratadine. Hence, the method here in described can be successfully applied in quality control of combined pharmaceutical dosage forms.
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Author(s): Rima M Bankar and Dipti B Patel
Montelukast , Desloratadine, Ratio Spectra Derivative Spectrophotometry, spectrophotometry