alexa Abstract | Simultaneous estimation of Rabeprazole Sodium and Lafutidine in Bulk and Pharmaceutical dosage form by RP-UPLC Method

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Objective: A reversed phase stability-indicating Ultra-Performance Liquid Chromatographic (UPLC) assay method was developed and validated for quantitative determination of Rabeprazole Sodium & Lafutidine in bulk drug and marketed dosage form. Method: a Phenomanex, C18 column, 150 × 2.5 mm, in Isocratic mode with mobile phase containing Acetonitrile: buffer (0.01 M Potassium di-hydrogen orthophosphate) pH 6.8 (60:40% v/v) was used. The flow rate was 1.2ml/min and detection was made at 215 nm. The retention time of Rabeprazole Sodium and Lafutidine was found to be 3.1 min and 5.8 min respectively. The developed method was validated using various analytical parameters viz., accuracy, linearity, precision, specificity, system suitability, robustness according to International Conference on Harmonization (ICH) Q2R1 guidelines. Result: The detector response was linear in the range of 40-120 μg/ml, 80-240 μg/ml for Lafutidine and Rabeprazole Sodium respectively and the readings of all the validation parameters are within the acceptance criteria. Conclusion: The Proposed UPLC method is reliable for the simultaneous estimation of Rabeprazole Sodium & Lafutidine in bulk and other solid dosage forms.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): V MANNUR PANDYA AADIT V S MASTIHOLIMATH K K HULLATTI P M DANDAGI A P GADAD

Keywords

Rabeprazole Sodium, Lafutidine, RP-UPLC, ICH guidelines

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords