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Short Communication Open Access
The simple, accurate and precise Vierodt's and Q-analysis UV Spectrophotometric method has been developed for the simultaneous determination of valdecoxib and tizanidine in combined tablet dosage form. Shimadzu UV-1601 instrument was used and the Î»max of valdecoxib and tizanidine was found to be 237 nm and 319 nm, respectively. In Q-analysis, the isoabsorptive point for both the drugs was found at 289.5 nm. The linearity range lies between 5-30 Î¼g/ml for valdecoxib and 0.5-3 Î¼g/ml for tizanidine at their respective wavelengths.
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Author(s): Vaishali Nagulwar M R Tajne Kanchan Upadhye Suparna Bakhle Shilpa Deshpande Rita Wadetwar