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Research Paper Open Access
The proposed method is a simple, accurate, precise, specific and rapid method for the simultaneous estimation of gatifloxacin and ornidazole in bulk and tablet formulations. A column in isocratic mode, with a mobile phase consisting of acetonitrile: 0.025 M potassium dihydrogen phosphate buffer (50:50 v/v) with 0.5% v/v of triethylamine and its pH adjusted to 3.0 with glacial acetic acid were used. The flow rate was set at 1.0 ml/min and UV detection was carried out at 300 nm. The retention time of gatifloxacin and ornidazole were 2.89±0.017 min and 4.21±0.022 min, respectively. Linearity of gatifloxacin and ornidazole were found in the range of 2-24 µg/ml and 5-60 µg/ml, respectively. The developed HPLC method was extended for dissolution studies. The dissolution testing was performed at 50 rpm and 100 rpm in 0.1 N hcL0 as dissolution medium by paddle method.