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Research Paper Open Access
A simple and economical dual wavelength spectrophotometric method has been developed for the simultaneous estimation of dextropropoxyphene hydrochloride and acetaminophen in combined dosage forms. The method was based on property of additivity of absorbances. The two wavelengths on acetaminophen curve were found out where it showed same absorbance, which were 216.6 and 262.9 nm. At 262.9 nm, acetaminophen showed some absorbance while dextropropoxyphene hydrochloride showed zero absorbance. Both the drugs gave absorbance at 216.6 nm. The method involved solving of an equation based on measurement of absorbances at two wavelengths 216.6 and 262.9 nm. The proposed method was found to be simple, economical, accurate and reproducible for the routine analysis of both drugs in capsule dosage forms.
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Author(s): S A Shah I S Rathod S S Savale V B Sutariya