alexa Abstract | SLE and Type 1 Diabetes Mellitus Leading to End Stage Renal Disease: A Case Report and Review of the Literature

Annals of Clinical and Laboratory Research
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Case Report Open Access

Abstract

Objective: Type I diabetes (T1D) and Systemic lupus erythematosus (SLE) are two autoimmune conditions. When occurring in the same patient, they can lead to deleterious end points if not managed aggressively and adequately. The aim of this report is to alert physicians on the seriousness of this combination by presenting the case of a patient with end stage renal disease secondary to T1D and SLE.

Methods: We present the case of a 32 year-old lady with long standing uncontrolled diabetes and 3 years history of SLE, who presented recurrently to our institution with her last admission for preparation for hemodialysis.

Results: Patient had progressive proteinuria and declining GFR since 2012 (first admission). Kidney biopsy was done twice (3 years apart) showing a mixture of lupus nephritis and diabetic nephropathy.

Conclusion: T1D and SLE share common immunological and molecular basis that can aggravate each other leading to important vascular end points.

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Author(s): Nisrine Ghazal and Sami Azar

Keywords

SLE, Diabetes Type 1, Hemodialysis, Clinical biochemistry, Laboratory research, Type 1 diabetes

 
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