alexa Abstract | ?Solid as Solvent?- Novel Technique for Spectrophotometric Analysis of Ornidazole Tablets Using Melted Phenol as Solvent

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Commonly used organic solvents for spectrophotometric analysis of water insoluble drugs include methanol, ethanol, chloroform, benzene, dichloromethane, dimethyl formamide, acetonitrile, ethyl acetate, toluene, carbon tetrachloride, acetone, hexane etc. The main drawbacks of organic solvents include high cost, toxicity and pollution. Organic solvents have numerous adverse effects caused by single exposure like dermatitis, headache, drowsiness, nausea, eye irritation and long term exposure causes serious effects such as neurological disorders, chronic renal failure, liver damage, necrosis, mutagenesis disorder. They should be replaced by other eco-friendly alternative sources. The present investigation is an attempt to show that solids can also be wisely used to act as solvent precluding the use of organic solvents. In a separate study, author has attempted soxhelation using phenol as solvent. The vapours of boiling phenol got condensed in extraction chamber to effect the extraction of active constituents from powder of crude drugs. The main objective of the present study is to demonstrate the solvent action of solids. Solid excipients can nicely be employed as solubilizers in the development of pharmaceutical dosage forms in solution form of poorly soluble drugs (mixed solvency concept). Present study describes the application of solvent character of melted phenol (at 50-60°C) for spectrophotometric estimation of ornidazole tablets. Solubility of ornidazole in distilled water is 8.03 mg/ml. More than 700 mg of ornidazole dissolves in one gram of melted phenol (at 50-60°C). In the present investigation, melted phenol (at 50-60°C) was utilized to extract out (dissolve) the drug from powder of ornidazole tablets. Distilled water was used for dilution purpose. Absorbances of standard solutions containing 5, 10, 15, 20 and 25 μg/ml were noted at 319 nm against reagent blanks to obtain calibration curve. Proposed method is novel, economic, eco-friendly, rapid, free from toxicity of organic solvent, accurate and reproducible. Recovery studies and statistical data proved the accuracy, reproducibility and precision of the proposed method. The presence of tablet excipients and phenol did not interfere in the spectrophotometric estimation at 319 nm. Phenol does not interfere in spectrophotometric estimation above 300 nm.

To read the full article Peer-reviewed Article PDF image

Author(s): Jain DK Patel V Banjare L Jain N Maheshwari RK

Keywords

Mixed-solvency concept, Ornidazole, Phenol, Spectrophotometric analysis

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords