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Short Communication Open Access
The Extended Hildebrand Solubility Parameter Approach (EHSA) is suggested to predict the solubility of drug in binary and ternary solvent blends. The solubility profile of metronidazole Dioxane-water blends shows a bell shaped curve with solubility maxima different from the calculated ideal solubility. The approach was found better for the prediction of solubility.
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Author(s): V K Mourya S K Yadav T R Saini