alexa Abstract | Solvent effects on molar refraction and polarizability of 4-amino-5- chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride hydrate solutions at 300C

Journal of Chemical and Pharmaceutical Research
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Original Articles Open Access


Molar refraction (RM) and polarizability (a) of binary 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride hydrate drug in different solvents like water, methanol, ethanol and dimethyl sulfoxide were computed from experimental density (r) and refractive index (nD) data at 300C. Enhancement in overall polarizability of drug solution with relative drug concentration in each solvent and strong drug-solvent interaction due to perturbation in structural orientation of drug indifferent solvent has been observed.

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Author(s): S D Deosarkar M P Pawar R T Sawale A R Hardas and T M Kalyankar


Density, Refractive index, Drug-solvent molecular interaction, molar refraction ,polarizability

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