alexa Abstract | Solvent free synthesis of alkyl 2-(dialkylamino)-4 phenylthiazole-5- carboxylates derivatives and in vitro antimycobacterial activity of these compounds against Mycobacterium smegmatis

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

The reaction between secondary amines, benzoyl isothiocyanate, and dialkyl acetylene dicarboxylates (dialkyl but- 2-ynedioates) in the presence of silica gel (SiO2) led to alkyl 2-(dialkylamino)-4-phenylthiazole-5-carboxylates in fairly high yields. The structures of these products were confirmed by their IR, 1H and13CNMR, and mass spectra determination. All compounds have been screened for antimicrobial activity against Mycobacterium smegmatis by broth dilution and agar well diffusion methods. All the synthesized derivatives exhibited remarkable activity against this bacterium.

To read the full article Peer-reviewed Article PDF image

Author(s): Maryam Kouhkan Nima Hosseini Jazani Ali Souldozi Minoo Zardashti and Narges Darabi

Keywords

Solvent free, 2-aminothiazol, Antimicrobial, Mycobacterium smegmatis, Mycobacterium

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords