alexa Abstract | Solvent free synthesis of alkyl 2-(dialkylamino)-4 phenylthiazole-5- carboxylates derivatives and in vitro antimycobacterial activity of these compounds against Mycobacterium smegmatis

Journal of Chemical and Pharmaceutical Research
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The reaction between secondary amines, benzoyl isothiocyanate, and dialkyl acetylene dicarboxylates (dialkyl but- 2-ynedioates) in the presence of silica gel (SiO2) led to alkyl 2-(dialkylamino)-4-phenylthiazole-5-carboxylates in fairly high yields. The structures of these products were confirmed by their IR, 1H and13CNMR, and mass spectra determination. All compounds have been screened for antimicrobial activity against Mycobacterium smegmatis by broth dilution and agar well diffusion methods. All the synthesized derivatives exhibited remarkable activity against this bacterium.

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Author(s): Maryam Kouhkan Nima Hosseini Jazani Ali Souldozi Minoo Zardashti and Narges Darabi


Solvent free, 2-aminothiazol, Antimicrobial, Mycobacterium smegmatis, Mycobacterium

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