alexa Abstract | Some cns depressant steroidal tetrazoles

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

Eight steroidal tetrazoles were studied for their CNS activity in mice. Their effects on analgesia, pentobarbital hypnosis, spontaneous motor activity and body temprature were examined. Compounds (2,3 and 4) showed CNS depressant activity in the above mentioned parameters. The other compounds tested had varying degrees of CNS activity. However, none of the compounds exhibited any anticonvulsant property in maximal electro-shock-induced convulsions, although compound (3) offered 80 percent protection against mortality.



Author(s): TR Bhardwaj SN Singh SK Kulkarni D Paul H Singh

 
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