alexa Abstract | Spectrophotometric Determination Of 4,4'-Sulphonyldianiline

Indian Journal of Pharmaceutical Sciences
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A simple, rapid and sensitive spectrophotometric method for the determination of 4,4'- sulphonyldianiline (dapsone) is described. The method is based on the formation of orange red coloured product by the diazotisation of dapsone followed by complexation with dopamine in presence of molybdate ions in 1:1 sulphuric acid medium. The product is stable for two days at 27o. Beer's law is obeyed in the concentration range of 0.1-8.0 μg/ml at 510 nm. The method is successfully employed for the determination of dapsone in tablets and common excipients used as additives in pharmaceuticals do not interfere. The method offers the advantages of simplicity,rapidity and sensitivity without the need for extraction or heating. Limit of detection and limit of quantification are reported.

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Author(s): P Nagaraja KR Sunitha HS Yathirajan RA Vasantha

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