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Research Paper Open Access
A spectrophotometric method is described to illustrate the utility of charge transfer-complexation in a non-aqueous medium for the assay of ketamine hydrochloride. Conformity to Beer's Law enabled the assay of dosage forms of the drug. Employing Job's method of continuous variation, chloranilic acid was found to form a charge-transfer complex in a stoichiometry with maximum absorption band at 528 nm for ketamine hydrochloride. The method has been successfully applied to the analysis of commercially available ketamine hydrochloride dosage forms without interference from their excipient.
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Author(s): G B Okide U E Odoh