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Short Communication Open Access
A simple, sensitive spectrophotometric method has been developed for the determination of lamivudine and stavudine In pure and its pharmaceutical formulations. Lamivudine and stavudine give green coloured chromogens with 3-methyl-2-benzothiozolinone hydrazone hydrocloride and ferric chloride with absorption maximum at 660 nm and 630 nm, respectively. The chromogens obey Beer's law in the concentration ranges of 2.5 to 40 Î¼g/ml and 2.5 to 12.5 Î¼g/ml, respectively for lamivudine and stavudine.
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Author(s): D G Sankar M V V N Reddy J M Rajendra Kumar T K Murthy