alexa Abstract | Spectrophotometric Determination Of Secnidazole In Tablets

Indian Journal of Pharmaceutical Sciences
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An extractive spectrophotometric method was established for the determination of secnidazole in pure and tablets using bromothymol blue as an analytical reagent. The method is based on the formation of a chloroform-extractable yellow colored ion-associated complex (bromothymol blue cation-secnidazole anion) through the reaction of secnidazole with an excess of bromothymol blue at pH 4.4. Beer's law was obeyed in the range of 2.0-40.0 µg/ml. The method is simple, precise and accurate for pure analyte with recovery (98.0-102.0%) and also, this does not require any separation of soluble excipients in tablets.

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Author(s): V Ravichandran V Sankar V Sivanand G Velrajan S Raghuraman

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