alexa Abstract | Spectrophotometric determination of silodosin in pharmaceutical formulations by charge transfer complex method

Journal of Chemical and Pharmaceutical Research
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Abstract

Highly sensitive, simple, and economical UV-spectrophotometric method has been developed for the determination of silodosin in bulk and dosage forms. The proposed method was based on the charge transfer reaction of selected drug as n-electron donors with acceptor 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) to form red color charge-transfer complexes. This reaction is instantaneous and quantitative. Silodosin has the maximum absorbance at 410 nm and Beer’s law limit was obeyed at 30-120 μg/ml. The optical characteristics of the proposed method such as molar absorptive, sand ell’s sensitivity, slope and intercept were 1.1254 L.mole-1cm-1, 0.0033 μg.cm-2, 0.0040 and 0.0014 for silodosin respectively. The developed method was found to be simple, specific, robust, accurate and precise for the determination of silodosin.

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Author(s): G Dill Rani and P Venkateswarlu

Keywords

Silodosin, chloroform, methanol, DDQ and UV-Spectrophotometric method, silodosin

 
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