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Research Paper Open Access
A simple and Sensitive method has been developed for the estimation of silymar in pharmaceutical formulations. The method is based on the reaction of silymarin with diazotised sulphanilic acid in alkaline medium to form orange red colored chromogen which exhibits absorption maximum at 460 nm. The chromogen formed is stable and Beer's law is obeyed in the concentration range of 2-10 mcg/ml. The probable mechanism of reaction is the coupling of diazo group in diazotised sulphanilic acid at 8th position of flavone ring which imparts intense orange red colour in alkaline medium. The proposed method is precise, accurate and reproducible and it is extended to the analysis of silymarin in pharmaceutical solid formulations.
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Author(s): A Rajasekaran M Kumar G Krishnamoorthy B Jayakar