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Simple, cost effective and reproducible spectrophotometric methods are proposed for the determination of enalapril maleate, lisinopril dihydrate, moexipril hydrochloride and ramipril hydrochloride in pure and tablet doage forms. The methods are based on oxidation of these drugs by either potassium dichromate or potassium permanganate in sulphuric acid medium then measuring of the developed colored reaction products or the decrease in the intensity of color at λmax 610, 520 nm for the potassium dichromate (method A) and potassium permanganate (method B) respectively. Different variables affecting the reaction conditions were carefully studied and optimized. Under optimal experimental conditions the linear range is 20-900 μg.ml-1 (method A) and 2-500 μg.ml-1 (method B). The proposed methods were successfully applied to the analysis of the investigated drugs in pure and tablet dosage form. Results were comparable with those obtained by reported spectrophotometric methods.
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Author(s): Mohamed HA Khashaba PY Shahin RY
Spectrophotometric, Enalapril maleate, Lisinopril dihydrate, Moexipril hydrochloride, Ramipril hydrochloride, Potassium dichromate, Tablets