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Accurate and economical spectrophotometric method requiring no prior separation has been developed. The method employs multiwavelength ultraviolet spectrophotometry for the simultaneous estimation of tinidazole, diloxanide furoate and furazolidone from tablet formulation using N,N-dimethylformamide (15% v/v) as solvent. The three wavelengths selected for analysis are 367 nm, 317 nm and 262 nm. All the three drugs obey Beer's law in the concentration ranges employed for the analysis. The results of analysis have been validated by application of statistical principles to the data obtained and the method was found to give satisfactory results.
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Author(s): A Sachan P Trivedi