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Short Communication Open Access
Four simple and sensitive visible spectrophotometric methods have been described for the determination of pyrantel based on the formation of coloured charge-transfer complex between drug and chloranilic acid (method A, Î»max : 540 nm) or by the reduction of Folin-Ciocalteau reagent (method B, Î»max : 760 nm) or by finding the oxidant [N-bromosuccinimide (NBS) or potassium permanganate (KmnO4)] reacted with pyrantel using a dye [celestine blue Î»max : 540 nm (method C) or cresyl fast violet acetate Î»max : 600 nm (method D)]. The results obtained are reproducible with coefficient of variation of less than 1.0%.
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Author(s): C S R Lakshmi M N Reddy