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Short Communication Open Access
A simple spectrophotometric method in visible region is described for estimation of amlodipine besylate and benidipine hydrochloride from their respective tablet formulations. The developed method is based on formulation of coloured chloroform extractable complex of drug with rhodizonic acid. Extracted complex of amlodipine besylate showed absorbance maxima at 450 nm while complex of benidipine hydrochloride showed absorbance maxima at 497.5 nm. Beer's law is obeyed in the concentration range of (0.1-1.5 mg/ml) for both the drugs. Results of analysis were validated statistically and by recovery studies.
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Author(s): I Singhvi S C Chaturvedi