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The present study describes a simple, accurate, precise and sensitive spectrophotometric method for the determination of linezolid (LZD) in pure and tablet forms. The method is based on the oxidation of LZD by Ferric citrate in the presence of 1,10-phenanthroline. The colored complex was measured at 510 nm. Beers law was observed in the concentration range of 1-10μg/ml with correlation coefficient 0.991. The method was validated for several parameters like accuracy, precision and linearity. The values of relative standard deviation and % recovery were found to be satisfactory, indicating that the proposed method is precise and accurate and can be used for the determination of Linezolid in tablet dosage forms.
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Author(s): Naik AD Pai SPN
Linezolid, Spectrophotometry, ferric citrate, 1, 10-phenanthroline.