alexa Abstract | Spectrophotometric method for Simultaneous estimation of Atorvastatin Calcium & Fenofibrate in tablet Dosage Form

International Journal of Drug Development and Research
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Abstract

A UV spectrophotometric method was developed for the estimation of atorvastatin calcium & fenofibrate in tablet dosage form by using simultaneous equation method. The drug obeyed Beer’s law & showed good correlation near to 0.999. Absorption maxima of atorvastatin calcium & fenofibrate were found to be at 246 and 286 nm respectively. Beer’s law was obeyed in concentration rang of 1-10 μg/ml for atorvastatin calcium & 2-20 μg/ml for fenofibrate. The method has been validated for linearity, accuracy & precision. The recovery was more than 99%. The developed method was found to be accurate, simple, precise, economical, and selective for simultaneous estimation of atorvastatin calcium & fenofibrate in tablet dosage form.

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Author(s): Hirave Rupali V Bendgude Ravindra D Maniyar Mithun G Kondawar Manish S Patil Sandeep B

Keywords

Simultaneous determination, atorvastatin calcium, fenofibrate, development and validation.

 
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