alexa Abstract | Spectrophotometric method for the estimation of Oxcarbazepine in tablets

Indian Journal of Pharmaceutical Sciences
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The objective of this work was to develop a simple, accurate, rapid and sensitive method for the estimation of oxcarbazepine in tablets. The estimation is based on the reduction of ferric ions in its salt form to ferrous ions by the drug, which in presence of potassium ferricyanide produces green colored chromogen measured at 770 nm against reagent blank. The chromogen obeyed linearity over 4 to 28 mg/ml (r=0.9981) with percent relative standard deviation (% RSD) of 0.4267. Recovery studies gave values ranging between 98.26 and 98.76. The proposed method is simple and suitable for routine determination of oxcarbazepine in tablets.

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Author(s): CS Ramaa PP Chothe AA Naik VJ Kadam

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