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Short Communication Open Access
Three simple, sensitive and accurate extractive colorimetric methods for estimation on benidipine hydrochloride from tablet formulation have been developed. The developed methods involve formation of coloured chloroform extractable ion pair complexes of the drug with bromocresol green (BCG), bromophenol blue (BPB) and thymol blue (TB) in acidic medium. Extracted complexes showed absorbance maxima at 408.5 nm (BCG), 404 nm (BPB) and 570 nm (TB) and Beer's law is obeyed in concentration range of 0 - 60 mg/ml, 0 - 40 mg/ml and 0 - 30 mg/ml respectively. Results of analysis were validated statistically and were found to be reproducible.
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Author(s): I Singhvi S C Chaturvedi