alexa Abstract | Spectrophotometric methods for the estimation of Cephalexin in tablet dosage forms

Indian Journal of Pharmaceutical Sciences
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Two simple, sensitive, accurate, rapid, and economical spectrophotometric methods, have been developed for the estimation of cephalexin in tablets. Method A is based on the reaction of cephalexin with Folin-Ciocalteu reagent, in presence of 20% sodium carbonate solution, giving a blue colour chromogen, which shows maximum absorbance at 753 nm against reagent blank, while method B is based on the estimation of cephalexin in distilled water, at 263 nm. Beer's law was obeyed in the concentration range of 10-160 µg/ml in method A, and 5-50 µg/ml in method B. Results of the analysis were validated statistically, and by recovery studies.

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Author(s): SA Patel NM Patel MM Patel

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