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Research Article Open Access
Simple, precise, rapid and accurate methods for simultaneous determination of Famotidine (FAM) and Domperidone (DOM) in combined tablet dosage form have been developed. First method is based on Ratio spectra derivative and second method uses Area under curve (AUC) and methanol is used as solvent. The amplitudes at 249.78 nm and 301.07 nm of the first derivative of ratio spectra were selected to determine FAM and DOM, respectively by ratio derivative method and wavelength ranges of 282.70 - 285.23 nm and 225.87 – 228.97 nm were selected to determine FAM and DOM by AUC method in combined formulation. Beer’s law is obeyed in the concentration range of 10-50 μg/mL and 5-25 μg/mL for Famotidine and Domperidone, respectively by both the methods. The % assay in commercial formulation was found to be in the range 99.01 – 100.90 % for FAM and 98.91 – 101.72 % for DOM by the proposed methods. The methods were validated with respect to linearity, precision and accuracy. Recovery was found in the range of 98.60 – 101.80 % for FAM and 98.75 – 100.2% for DOM by ratio derivative method and 98.16 – 100.4% for FAM and 98.89-100.21% for DOM by AUC method. The methods developed are simple, economical, precise and accurate and can be used for routine quality control of combined tablets.
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Author(s): Dipali D Tajane Sacchidanand R Gite Aditi R Shah Arun B Kale Ranjit V Gadhave and Vishnu P Choudhari
Famotidine, Domperidone, Ratio Spectra Derivative Spectrophotometry, Area Under Curve.