alexa Abstract | Spectroscopic and thermal investigations on charge-transfer complexes formed in the reaction of pregabalin drug and various acceptors

Journal of Chemical and Pharmaceutical Research
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Abstract

Charge-transfer complexes formed between pregabalin as electron donor with different electron acceptors, picric acid (HPA), chloranilic acid (H2CA) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) have been studied in the liquid and solid states. The stoichiometries of complexes were found to be 1:1 molar ratio between donor and acceptors for the systems PRG-HPA and PRG-H2CA while a ratio of 1:2 was detected for the PRG-DDQ interaction at the characteristics CT absorption bands of the formed complexes. Characterizations of the formed CT-complexes were based on elemental analyses, photometric titration measurements, IR, 1H NMR spectra along with the thermogravimetric analysis of the CT-complexes. The characteristic physical constants (KCT), (m), (DG), (ID), (f), (ECT) of the formed CT-complexes are shown to be strongly dependent on the type and structure of the electron acceptors.



Author(s): Mahmoud M Alia Akmal S Gaballab Reda A Haggama Nabila A ElKhososya and Said M Teleba

Keywords

Charge transfer, Pregabalin, DDQ, H2CA, HPA, charge-transfer complexes

 
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