700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ ReadersThis Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
The interaction of native calf thymus DNA (ctDNA) with solifenacin succinate (SFS) was investigated under simulated physiological conditions by multi-spectroscopic techniques and viscometric measurements. It concluded that SFS could intercalate into the base pairs of ctDNA, and the fluorescence quenching by ctDNA was static quenching type. Thermodynamic parameters calculated suggested that the binding of SFS to ctDNA was mainly driven by hydrophobic interactions. Furthermore, the relative viscosity of ctDNA increased with the addition of SFS, which confirmed the intercalation mode.
To read the full article Peer-reviewed Article PDF
Author(s): Gowda BG Mallappa M Mahesh RT Hadimani CC
Solifenacin succinate, Calf thymus DNA, spectroscopic, Viscositic studies