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Spherical agglomeration technique is a specialized and modern method which has been successfully employed to improve flowability, packability, Compressibility, wettability, solubility, and bioavailability of various poorly soluble and poorly Compressible drugs. The different Techniques discussed are Crystallization method, Solvent crystallization method, Quasi- emulsion diffusion method, Ammonia Diffusion method, neutralization method, and solvent agglomeration technique. This article gives a detailed and comprehensive review about different techniques, its advantages, mechanism and application of Spherical agglomeration Technique along with its Evaluation and Characterization methods. The spherical crystals can be Evaluated using FTIR (Fourier Transformation Infra red technique) DSC (Differential Scanning Calorimetry) X-ray Diffraction and Chromatographical methods. This technique also finds its application in improving taste of bitter drugs and in the preparation of nanospheres, microspheres and nano-particles.
Spherical Crystallization, Techniques of Crystallization, Mechanism, Evaluation, Characterization.