alexa Abstract | Stability indicating and validation by RP-HPLC for the estimation of Ziprasidone in bulk and its dosage Form

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

A new simple, sensitive and stability indicating RP-HPLC method for the determination of ziprasidone in pharmaceutical dosage form was developed. Chromatographic separation was carried on RP-C8 column (symmetry 250x4.6mm;5μm) with a mobile phase composed of potassium dihydrogen phosphate buffer (pH 4.5) and acetonitrile (70:30) at an absorption maxima 247nm. Linearity for detector response was observed in the concentration range of 50- 150% of test concentration. Correlation coefficient found to be 1.0. Retention time was found to be 4.1min. Percent recovery studies were found in the range 50-150% of test concentration. Drug product was exposed to acid, base, heat, oxidation and photolytic stress conditions and the samples were analysed by the proposed validated method. Results of the analysis were validated statistically and by recovery studies. The developed method was found to be precise for the determination of ziprasidone in bulk and capsule dosage form.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Ramesh babu A Vijaya lakshmi M Lavanya G

Keywords

Ziprasidone, RP-HPLC, 5HT2A receptor antagonist, Capsule dosage form.

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords