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Short Communication Open Access
A stability indicating simple, rapid and precise reversed-phase HPLC method has been developed for the quantitation of pioglitazone in tablet on a Hypersil C-8 (250x4.6 mm) column using a mobile phase consisting acetonitrile:0.15% v/v triethylamine (40:60 v/v) adjusted to pH 4.6 with orthophosphoric acid at a flow rate of 1.5 ml/min and detection at 220 nm. The retention time of pioglitazone have been found to be 7.6 min and recoveries were between 99-101%. Validation of the proposed method also been done.
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Author(s): D B Wanjari N J Gaikwad