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Research Article Open Access
An isocratic stability indicating liquid chromatographic method has been developed and validated for the determination of Pramipexole in bulk drug and its pharmaceutical dosage forms. Separation of the drug with degradation products was achieved using Prontosil,C18, 150 x 4.6mm; 5μm column as stationary phase and pH 3.0(±0.05) buffer: Acetonitrile (72:28,v/v) as mobile phase at a flow rate of 1.0 mL/min. UV detection was performed at 264 nm. The method is linear over the range of 0.96 – 89.7 μg/mL. The percent recovery of drug in dosage forms was ranged from 100 to 102.2. The method is simple, rapid, precise, selective and stability indicating and can be used for the assay in quality control and stability studies samples.
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Author(s): R Narendra Kumar G Nageswara Rao P Y Naidu