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Research Paper Open Access
Stability studies of rifampicin mucoadhesive nasal drops were performed by using accelerated stability testing analysis. Effect of temperature and antioxidants were studied. As the temperature increases the rate of degradation was increased and at individual temperatures the rate of degradation was more with increasing time. The stability was improved to certain extent by adding one or more antioxidants such as ascorbic acid and sodium sulfite. The pH changes are within pH 5 and pH 6 due to the influence of polymer (HPMC K4M). The optimally formulated nasal drops could have 90% active drug at the end of 17 days if stored at 36.
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Author(s): Y Madhusudan Rao K Maruthi Devi R Bala Ramesha Chary