alexa Abstract | Stability Study of Griseofulvin in Non Aqueous Microemulsion System

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

New non aqueous based microemulsion allows the delivery of storage sensitive personal care actives in conventional cream, lotion and gel. Griseofulvin is an antifungal antibiotic drug micro emulsion system as the basic formulation for investigation. The quantity of griseofulvin and the accumulation of anhydrous micro emulsions at various temperatures were analyzed with poor aqueous solubility. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. Pharmaceutical and cosmetic micro emulsions are normally oil-in-water (o/w) or water-in-oil (w/o) systems; however, micro emulsions can be formulated with no aqueous phase to produce an anhydrous micro emulsion system. An anhydrous micro emulsion system could offer a stable vehicle for compounds that are sensitive to hydrolysis or oxidation. Therefore, to enhance the stability of griseofulvin in formulations, we chose the non aqueous, anhydrous through an established ultra violet (uv) method. The results indicated that Stability of griseofulvin in non aqueous microemulsion carried out at at temperature 5°C, 25°C and 40°C. Cream was stable at 5°C and 25°C. Stability studies were carried out at agitation, centrifugation, freeze thaw cycle, in that evaluated various parameter i.e phase separation, globule size, viscosity, drug content.

To read the full article Peer-reviewed Article PDF image

Author(s): Jadhav CM Kate VK Payghan SA

Keywords

Non-aqueous micro emulsion, Griseofulvin, Stability

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us