alexa Abstract | Strategies for enhanced drug delivery to the central nervous system

Indian Journal of Pharmaceutical Sciences
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Review Article Open Access

Abstract

Treating central nervous system diseases is very challenging because of the presence of a variety of formidable obstacles that impede drug delivery. Physiological barriers like the blood-brain barrier and blood-cerebrospinal fluid barrier as well as various efflux transporter proteins make the entry of drugs into the central nervous system very difficult. The present review provides a brief account of the blood brain barrier, the P-glycoprotein efflux and various strategies for enhancing drug delivery to the central nervous system.

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Author(s): VSNM Dwibhashyam AN Nagappa

Keywords

CNS drug delivery, p-glycoprotein, nano particles, blood brain barrier

 
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