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Research Article Open Access
The present study was used to evaluate the effects of naturally occurring antioxidants vitamin-E, morin, rutin and quercetin on the doxorubicin (DOX)-induced cardiomyopathy in a rabbit model. The authors evaluated the ameliorative effects flavonoids and vitamin-E against DOX administration. Thirty New Zealand white rabbits aged between 5-6 months and averaging 2.5-3.0 kg in weight were divided into 5 groups of 6 in each were treated with vitamin E (50 IU/kg body weight) and flavonoids morin, rutin and quercetin (20mg/kg body weight) for four weeks and two doses of doxorubicin (10mg/kg body weight) at the end of 28 days. The flavonoids affected the levels of serum enzymes SGOT, SGPT, ALP, minerals Sodium, Potassium and Phosphorus, oxidative markers catalase (CAT), lipid peroxidation, glutathione-stransferase (GST), reduced glutathione (GSH) both in whole erythrocytes and tissues of liver, heart and kidneys. The study concludes that the flavonoids have a protective role in the abatement of doxorubicininduced cardiomyopathy by regulating the oxidative stress.
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Author(s): Raja Kumar Parabathina EMuralinath P Lakshmana Swamy V V S N Hari Krishna and G Srinivasa Rao
Doxorubicin, cardiomyopathy, flavonoids, oxidative stress, serum enzymes, oxidative markers