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Original Articles Open Access
Clotrimazole was formulated as a tablet lozenge to provide slow release medicament for the treatment of oral thrush in pediatric patients. Th ere are dosage forms like syrups, tablets in the market but still there is a need for new dosage for ms which acts effectively and locally. So the present investigation aims to design, prepare and e valuate tablet lozenge of Clotrimazole. The benefits of these prepared lozenges are increased b ioavailability, reduction in gastric irritation by passing first pass metabolism. The lozenges were prepared by heating and congealing method in a candy based industry on request using sucrose as base. All the formulations prepared were subjected to various physico-chemical parameters li ke hardness, content uniformity, friability, weight variation etc. The prepared formulations hav e a hardness of 10-12 Kg./cm², free from gritty particles, and good taste. Stability study of selected formulations were also carried out at 37ºC for a period of six months. Selected formulat ions were tested for drug excipient interactions subjecting to IR Spectral analysis. I n-vitro drug dissolution studies showed 86.08% for F1 and 79.80% for F2 release of drug in 30 minu tes, 95.01% in 7 minutes from F0 formulation. The tablet lozenges can provide an att ractive alternative formulation in the treatment of oral thrush in pediatric patients.
Clotrimazole, lozenges, oral thrush., lozenges