alexa Abstract | Studies on enhancement of dissolution rate of etoposide

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


Dissolution is the rate-limiting step in the absorption of drugs from solid dosage forms. This is to be focused especially when the drug is poorly soluble. Etoposide is a poorly soluble drug and its absorption is dissolution rate limited. The present study is aimed at improving the dissolution of etoposide. Solid dispersions of drug with surfactants were prepared by using kneading technique. Kneading technique is more applicable to industry. Surfactants such as cetrimide, sodium lauryl sulphate, Tween 80 and Cremophor RH40 were used in different proportions. Etoposide gave faster dissolution rates when Cremophor RH40 was used. The DSC thermograms and IR spectra revealed no interaction of etoposide with these surfactants and no degradation in etoposide molecule was observed.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Y Prasanna Raju Asuntha Garbhapu SAL Prasanna B Sreenivasa Rao KV Ramana Murthy

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version