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Research Paper Open Access
Methanol extract of roots of Cocculus hirsutus was tested for its hypoglycemic and cardiotonic effects on diabetic rats and isolated perfused frog heart respectively. The methanol extract exhibited significant hypoglycemic activity on diabetic rats and cardiotonic activity on normal and hypodynamic frog heart preparation. Activity-guided fractionation of methanol extract was carried out. Butanol fraction of methanol extract of roots of C. hirsutus was found to have significant cardiotonic activity comparable to that of ouabain. Total alkaloid fraction prepared from methanol extract showed considerable hypoglycemic activity on alloxan-induced diabetic rats. The TLC profile of total alkaloid fraction showed the presence of four alkaloids, whereas the TLC profile of butanol fraction showed the presence of steroids and/or triterpenoids.