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Original Articles Open Access
Indole and its analogous are very good pharmacophores exhibiting wide spectrum of fungicidial, bactercidial and tuberculostic activities.These have poor solubility in polar medium which may be a limiting factor reducing their bio-accessibility. The solubility of these compounds in aqueous medium( polar medium) can be enhanced by forming inclusion complexes with a nontoxic oligosaccharide, namely β-cyclodextrin. In this paper an attempt has been made to synthesise some [arylidenamino]-1,3,4-thiadiazino[6,5b]indoles with activating(Hydroxy)and deactivating(Nitro)groups in their purest form and then to prepare their respective inclusion complexes with β-cyclodextrin. The formation of compounds and their inclusion complexes have been ascertained from elemental analysis and study of spectral characterstics. Thermodynamics properties of the inclusion complexes are also studied to know whether the formation of inclusion complex is thermodynamically stable or not. In addition,the study of thermodynamic properties also reveal the type of interaction existing in between the host β-cyclodextrin and the compound concerned.
Indole, [Arylidenamino]-1,3,4-theadiazino[6,5b]indoles, β-Cyclodextrin, Inclusion complex.