alexa Abstract | Studies on inclusion complexes of substituted indole derivatives with activating and deactivating group

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


Indole and its analogous are very good pharmacophores exhibiting wide spectrum of fungicidial, bactercidial and tuberculostic activities.These have poor solubility in polar medium which may be a limiting factor reducing their bio-accessibility. The solubility of these compounds in aqueous medium( polar medium) can be enhanced by forming inclusion complexes with a nontoxic oligosaccharide, namely β-cyclodextrin. In this paper an attempt has been made to synthesise some [arylidenamino]-1,3,4-thiadiazino[6,5b]indoles with activating(Hydroxy)and deactivating(Nitro)groups in their purest form and then to prepare their respective inclusion complexes with β-cyclodextrin. The formation of compounds and their inclusion complexes have been ascertained from elemental analysis and study of spectral characterstics. Thermodynamics properties of the inclusion complexes are also studied to know whether the formation of inclusion complex is thermodynamically stable or not. In addition,the study of thermodynamic properties also reveal the type of interaction existing in between the host β-cyclodextrin and the compound concerned.

Author(s): Sunakar Panda and Jagat Krushna Tripathy


Indole, [Arylidenamino]-1,3,4-theadiazino[6,5b]indoles, β-Cyclodextrin, Inclusion complex.

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version